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Keepingyouawake application11/28/2023 This may show that caffeine can speed up mental fatigue by activating more of the brain, but without an increased feeling of tiredness. However, the plasma branched-chain amino acid levels in the caffeine group were lower than those observed in the placebo group after the fatigue-inducing mental tasks. Task performance of the caffeine group was better than the performance observed in the placebo group but the subjective perception of fatigue, motivation, and sleepiness did not differ between both groups. Fatigue was induced by mental task performance. As described in a 2011 meta analysis, a small study examined levels of amino acids in 17 healthy participants who randomly received 100 mg/day of caffeine or a placebo twice a day for eight consecutive days. Plus, research suggests people who regularly consume caffeine have more adenosine receptors, making them more sensitive to the compound and its sleepiness effects.Ĭaffeine might also affect sleep by an effect on branched-chain amino acids, which are a biomarker of mental fatigue. Sometimes you’ll feel even more tired than before, as adenosine has been building up in the background. But when caffeine has blocked adenosine receptors, adenosine can’t bind to them, meaning the compound can’t make you feel tired.Ĭaffeine also increases your heart rate and triggers the release of adrenaline and cortisol, making you feel alert and ready for action.Ĭaffeine eventually wears off and adenosine can then bind to adenosine receptors again, meaning you start feeling tired. As levels rise, we start to feel more and more tired and we eventually get the urge to go to sleep - this is known as sleep pressure.Īdenosine acts as a neurotransmitter, depressing the central nervous system and sending messages to the brain to tell it when to rest. ![]() These compounds then temporarily block the A1 and A2 adenosine receptors in your brain.Īdenosine is a natural compound that builds up in your body all the time you’re awake. ![]() When we consume caffeine, enzymes in the liver metabolize it into paraxanthine and theophylline. We know caffeine makes us feel more alert, but what exactly is going on behind the scenes?
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